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A major clinical trial found that participants who discontinued semaglutide lost about two-thirds of the weight they had previously lost over one year

This investigational peptide mimics the natural hormone amylin (also known as islet amyloid polypeptide or IAPP), which plays a crucial role in glucose homeostasis and satiety regulation [1]

The effect is modest at the individual level but statistically robust across nearly 28,000 patients and replicated in an independent NIH All of Us cohort

Patients who were randomized to glimepiride were initially treated with 2 mg daily for two weeks, increasing to 4 mg daily for another two weeks, and finally increasing to 8 mg daily